West of Loathing was originally released in 2017, by developer Asymmetric Publications. It is a spinoff of long-running web browser MMORPG Kingdom of Loathing, and maintains similar mechanics, terminology, and stick figure visuals from. A DLC scenario, Reckonin’ at Gun Manor, was released in 2019, and a follow-up game themed around a Lovecraftian setting was released without prior announcement in November 2022.

West of Loathing follows the adventures of the player-created protagonist, who can take the role of a Cow Puncher, Beanflinger, or Snake Oiler (fighter, mage, and ranger, respectively). After leaving their mundane family life behind, the protagonist journeys their way west, with the thriving town of Frisco as their destination. After first traveling to Boring Springs, the player picks up a horse for traveling and a pardner to assist in combat, before heading to a larger region divided by the mountains. Along the way, the protagonist tangles with demonic cows, evil rodeo clowns, mysterious alien technology, necromancy, cultists, and ghost bureaucracy.